What is the Mandelic acid?

Mandelic acid is white to light yellow crystal powder, while it's Molecular Formula is C8H8O3. white to light yellow crystal powder (R)-(?)-Mandelic acid can be used:As a chiral acid in the separation of diastereomeric salts for the synthesis of chiral pyridoindole based building block.In the study of chiral acid selectivity of poly(3,4-ethylenedioxythiophene) (PEDOT) based chiral conducting?polymers.

What is the CAS number for Mandelic acid?

The CAS number of Mandelic acid is 611-71-2.

What is Mandelic acid (611-71-2) used for?

Mandelic acid, also known as (R)-(-)-Mandelic acid, is a chiral resolving agent and a building block used in the synthesis of pharmaceutical drugs such as penicillin and cephalosporin. It is a white to light yellow crystal powder that can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme.InChI:InChI=1/C9H10O3/c1-6(10)7-4-2-3-5-8(7)9(11)12/h2-6,10H,1H3,(H,11,12)/t6-/m1/s1

What is the Mandelic acid?

Mandelic acid is white to light yellow crystal powder, while it's Molecular Formula is C8H8O3. white to light yellow crystal powder (R)-(?)-Mandelic acid can be used:As a chiral acid in the separation of diastereomeric salts for the synthesis of chiral pyridoindole based building block.In the study of chiral acid selectivity of poly(3,4-ethylenedioxythiophene) (PEDOT) based chiral conducting?polymers.

What is the CAS number for Mandelic acid?

The CAS number of Mandelic acid is 611-71-2.

What is Mandelic acid (611-71-2) used for?

Mandelic acid, also known as (R)-(-)-Mandelic acid, is a chiral resolving agent and a building block used in the synthesis of pharmaceutical drugs such as penicillin and cephalosporin. It is a white to light yellow crystal powder that can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme.InChI:InChI=1/C9H10O3/c1-6(10)7-4-2-3-5-8(7)9(11)12/h2-6,10H,1H3,(H,11,12)/t6-/m1/s1

D-Mandelic Acid

Basic information

Product Name:D-Mandelic Acid
CasNo.:611-71-2
MF:C₈H₈O₃
MW:152.15

Physical and Chemical Properties

Purity:99%
Boiling Point:131-133 °C(lit.)
Packing:white to light yellow crystal powder
Throughput:

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Product Details

CasNo： 611-71-2

MF： C₈H₈O₃

Appearance： white to light yellow crystal powder

Buy cost-effective 99% pure D-Mandelic Acid 611-71-2 now

Molecular Formula:C8H8O3
Molecular Weight:152.15
Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:5.14E-05mmHg at 25°C
Melting Point:131-133 °C(lit.)
Refractive Index:-153.5 ° (C=1, H2O)
Boiling Point:321.8 °C at 760 mmHg
PKA:3.37(at 25℃)
Flash Point:162.6 °C
PSA：57.53000
Density:1.321 g/cm³
LogP:0.80460

Mandelic acid(Cas 611-71-2) Usage

Synthesis Reference(s)	The Journal of Organic Chemistry, 33, p. 2565, 1968 DOI: 10.1021/jo01270a105Synthetic Communications, 18, p. 2141, 1988 DOI: 10.1080/00397918808068285
Flammability and Explosibility	Nonflammable
General Description	(R)-(-)-Mandelic acid, a chiral resolving agent, is also used as a building block to synthesize pharmaceutical drugs such as penicillin and cephalosporin. It can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme.

InChI:InChI=1/C9H10O3/c1-6(10)7-4-2-3-5-8(7)9(11)12/h2-6,10H,1H3,(H,11,12)/t6-/m1/s1

611-71-2 Relevant articles

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Lewkowitsch

, p. 1574,2722 (1883)

Enantioseparation of Mandelic Acid Enantiomers with Magnetic Nano-Sorbent Modified by a Chiral Selector

Tarhan, Tuba,Tural, Bilsen,Tural, Servet,Topal, Giray

, p. 835 - 842 (2015)

In this study, R(+)-α-methylbenzylamine-...

Process Development for the Production of (R)-(-)-Mandelic Acid by Recombinant Escherichia coli Cells Harboring Nitrilase from Burkholderia cenocepacia J2315

Wang, Hualei,Fan, Haiyang,Sun, Huihui,Zhao, Li,Wei, Dongzhi

, p. 2012 - 2016 (2015)

(R)-(-)-Mandelic acid is an important ch...

An organic solvent and thermally stable lipase from Burkholderia ambifaria YCJ01: Purification, characteristics and application for chiral resolution of mandelic acid

Yao, Changjin,Cao, Yan,Wu, Shanshan,Li, Shuang,He, Bingfang

, p. 105 - 110 (2013)

A solvent-tolerant bacterium Burkholderi...

Highly efficient resolution of mandelic acid using lipase from Pseudomonas stutzeri LC2-8 and a molecular modeling approach to rationalize its enantioselectivity

Cao, Yan,Wu, Shanshan,Li, Jiahuang,Wu, Bin,He, Bingfang

, p. 108 - 113 (2014)

Mandelic acid, a key precursor of chiral...

R-mandelic acid production with immobilized recombinant Escherichia coli cells in a recirculating packed bed reactor

Zhang, Xin-Hong,Liu, Zhi-Qiang,Xue, Ya-Ping,Yang, Bo,Xu, Ming,Zheng, Yu-Guo

, p. 205 - 211 (2016)

A recirculating packed bed reactor (RPBR...

Optical Resolution of Phenylalanine and Mandelic Acid

Yamamoto, Yasushi,Kato, Shinji,Yamashita, Hiroshi,Maekawa, Takashi

, p. 3149 - 3152 (1992)

The optical resolutions of phenylalanine...

Screening for enantioselective nitrilases: Kinetic resolution of racemic mandelonitrile to (R)-(-)-mandelic acid by new bacterial isolates

Kaul, Praveen,Banerjee, Anirban,Mayilraj,Banerjee, Uttam C.

, p. 207 - 211 (2004)

Several new microorganisms have been iso...

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Ingersoll,Babcock,Burns

, p. 411,414 (1933)

-

Woehler

, p. 240 (1848)

Surface functionalization of chitosan-coated magnetic nanoparticles for covalent immobilization of yeast alcohol dehydrogenase from Saccharomyces cerevisiae

Li, Gui-Yin,Zhou, Zhi-De,Li, Yuan-Jian,Huang, Ke-Long,Zhong, Ming

, p. 3862 - 3868 (2010)

A novel and efficient immobilization of ...

Nucleation and growth kinetics of (R)-mandelic acid from aqueous solution in the presence of the opposite enantiomer

Zhang, Yan,Mao, Shimin,Ray, Ajay K.,Rohani, Sohrab

, p. 2879 - 2887 (2010)

Resolution of mandelic acid (MA), a race...

Constituents of Prunus zippeliana leaves and branches

Kitajima,Tanaka

, p. 2007 - 2009 (1993)

The following substances were identified...

Improvement of alcaligenes faecalis nitrilase by gene site saturation mutagenesis and its application in stereospecific biosynthesis of (R)-(-)-mandelic acid

Liu, Zhi-Qiang,Zhang, Xin-Hong,Xue, Ya-Ping,Xu, Ming,Zheng, Yu-Guo

, p. 4685 - 4694 (2014)

Nitrilases have recently received consid...

Gene cloning, expression, and characterization of a nitrilase from Alcaligenes faecalis ZJUTB10

Liu, Zhi-Qiang,Dong, Li-Zhu,Cheng, Feng,Xue, Ya-Ping,Wang, Yuan-Shan,Ding, Jie-Nv,Zheng, Yu-Guo,Shen, Yin-Chu

, p. 11560 - 11570 (2011)

Nitrilases are important industrial enzy...

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Marckwald,Mc Kenzie

, (1901)

Designing of amino functionalized imprinted polymeric resin for enantio-separation of (±)-mandelic acid racemate

Alhawiti, Aliyah S.,Monier,Elsayed, Nadia H.

, (2021/02/12)

S-Mandelic acid (MA) enantio-selective r...

High-yield DL-mandelic acid synthesis process

-

, (2021/09/04)

The invention provides a high-yield DL-m...

Enantioseparation of mandelic acid and substituted derivatives by high-performance liquid chromatography with hydroxypropyl-β-cyclodextrin as chiral mobile additive and evaluation of inclusion complexes by molecular dynamics

Shi, Jie-Hua,Lin, Zhen-Yi,Kou, Song-Bo,Wang, Bao-Li,Jiang, Shao-Liang

supporting information, p. 675 - 684 (2021/08/16)

The enantioseparation and resolution mec...

Synthesis of α-hydroxycarboxylic acids from various aldehydes and ketones by direct electrocarboxylation: A facile, efficient and atom economy protocol

Singh, Kishanpal,Sohal, Harvinder Singh,Singh, Baljit

, p. 839 - 845 (2021/04/09)

In present work, the formation of α-hydr...

611-71-2 Process route

: 4542-46-5
2-(morpholin-4-yl)ethanethiol

: 1075-06-5
2,2-dihydroxy-1-phenyl-ethanone

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

Conditions

Conditions	Yield
With water;

: 56-23-5
tetrachloromethane

: 4393-06-0
1-Phenyl-2-propen-1-ol

: 64-18-6
formic acid

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 65-85-0,8013-63-6
benzoic acid