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CasNo： 33069-62-4
MF： C47H51NO14
Appearance： white powder
Cost-effective customized wholesale Paclitaxel 33069-62-4 We supply high quality Paclitaxel (CAS 33069-62-4), in stock, factory directly supply to clients, lower prices, more competitiveness.
Paclitaxel is white powder, while it's Molecular Formula is C47H51NO14. Paclitaxel is an antineoplastic that used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It is also used in the study of structure and function of microtubles into tubulin.
The CAS number of Paclitaxel is 33069-62-4.
More information of Paclitaxel 33069-62-4 are:
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Synonyms |
BMS 181339-01;Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alpha-R*,beta-S*),11-alpha,12-alpha,12a-alpha, 12b-alpha))-;Taxol.RTM. (Registered Trademark);QW 8184;MBT 0206;12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine;Palcitaxel;Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-;Prestwick_459;Abraxane;Taxol (TN);Paxceed;NSC-125973;Paxene;Plaxicel;Onxol;Indirubin;Paclitaxle;Paclitaxel Semi-Synthetic USP30; |
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CAS Number |
33069-62-4 |
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Molecular Formula |
C47H51NO14 |
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Molecular Weight |
853.92 |
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Density |
1.39 g/cm3 |
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Melting Point |
213 °C |
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Boiling Point |
957.115 °C at 760 mmHg |
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Flash Point |
532.644 °C |
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HS CODE |
2939.90 |
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PSA |
221.29000 |
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LogP |
4.12660 |
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Pka |
11.90±0.20(Predicted) |
Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer. Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death. The supply of paclitaxel is limited by its low natural abundance and currently it is being manufactured by a semi-synthetic route from deacetylbaccatin Ⅲ that is isolated from the needles of the yew tree. Recent completion of two total syntheses of taxol conquered the structural complexity of the title compound and may be useful in obtaining certain closely related analogs, some of which have been found to have antitumor activity. Paclitaxel has potential uses in the treatment of metastatic breast cancer, lung cancer, head and neck cancer, and malignant melanoma.
InChI:InChI=1/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31?,32-,33+,35?,36?,37+,38?,40?,45+,46-,47+/m0/s1
Articles related to Paclitaxel:
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Article |
Source |
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Semi-synthesis of paclitaxel from naturally occurring glycosidic precursors |
Rao, Koppaka V. , p. 675 - 680 (1997) |
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A clickable caging group as a new platform for modular caged compounds with improved photochemical properties |
Suzuki, Akinobu Z.,Sekine, Ryota,Takeda, Shiori,Aikawa, Ryosuke,Shiraishi, Yukiko,Hamaguchi, Tomomi,Okuno, Hiroyuki,Tamamura, Hirokazu,Furuta, Toshiaki , p. 451 - 454 (2019) |
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